Interestingly, in our study, overactivation of S6K1 upon DEPTOR depletion in prostate cancer cells and mice tissues did not inactivate PI3K/AKT signal (Figs. 2c, 3c, f, 4g, h, 6d, and Supplementary Fig. 3C). The gene discussed is RPS6KB1; the disease is Familial prostate cancer.