PTEN and neoplasm: Specifically, in all tested pairs of mice derived from three independent litters at the age of 13–16 months, the size of the prostates of Deptor−/−;Pten+/− mice, compared with those of Deptor+/+;Pten+/− mice, was much larger, and enlarged mass was covered with rich vascular anastomose, accompanied with hepatomegaly and focal tumor necrosis (Fig. 6a, Supplementary Fig. 7A).