In addition, there was a significantly higher expression of cleaved caspase-3 in tumors treated with IA gemcitabine (19.0 ± 7.2 positive cells/μm2) and high IV gemcitabine (22.2 ± 9.8 positive cells/μm2) when compared to tumor samples from animals treated with low IV gemcitabine (4.8 ± 1.3 positive cells/μm2; P < 0.05; Fig. 6). The gene discussed is CASP3; the disease is neoplasm.