Intriguingly, the expression of sox2/β-catenin in the shark SL is consistent with the proliferative, columnar peripheral edges of the ameloblastomas (Fig. 4A), whereas the DLRs show more peripherally restricted and limited sox2+ cells compared to the activated β-catenin expression present in the cytoplasm of entire DLRs. This evidence concerns the gene SOX2 and ameloblastoma.