GBA1 and Parkinson disease: For example, mutations in the glycolipid-metabolizing enzyme glucocerebrosidase (GBA1) are common in the familiar forms of Parkinson’s disease, while single-nucleotide polymorphisms of genes involved in other aspects of lipid metabolism [e.g., ASAH162, PLA2G663 and SMPD164] have been detected in the sporadic and more frequent form of this disorder.