HOMER1 and Alzheimer disease: This was performed by using intracellular injection of bioactive molecules or proteins such as inositol trisphosphate (IP3), homer1a and amyloid-β through a patch pipette12–17, and the results obtained by these methods were compatible with those observed in neurons having physiologically produced IP3 or homer1a proteins in cytoplasm, or in neurons of 3xTg Alzheimer’s disease model mice12–17.