Activated THP-1 macrophages and pancreatic cancer cells were cocultured in the 0.4-μm transwell system, and the Mφ macrophages cocultured with pancreatic cancer cells became a CD163+ M2 phenotype (Fig. 4a), which was similar to the phenotype of TAMs in the tumor tissue. Here, CD163 is linked to familial pancreatic carcinoma.