Then, the pancreatic cancer cells were incubated with various concentrations of IL-6 (0, 0.01, 1, 10 and 100 nM), and the CD59 expression and phosphorylation levels of STAT3 in cancer cells were significantly elevated to levels comparable to those in cells stimulated with THP-1 macrophages (Fig. 5h). Here, STAT3 is linked to pancreatic neoplasm.