Immunohistochemical examination of 10 distinct tumors showed that in most of the tumors, Tomato+ tumor cells express melanocytic markers Dct and MITF, neuronal markers Nestin, Tubb3 and Gfap, mesenchymal marker Pdgfra and proliferation marker Ki67 (Supplementary Fig. 12d). The gene discussed is TUBB3; the disease is neoplasm.