To ask if oncogenic McSCs can form melanomas, we generated c-Kit-CreER; BrafCA/+; Ptenfl/fl (c-Kit-CreER:Braf:Pten); R26R-mTmG (c-Kit-CreER:Braf:Pten:GFP) mice that inducibly express BrafV600E and delete Pten only in c-Kit+ McSCs7. Here, BRAF is linked to melanoma.