CAV1 and posterior cortical atrophy: To examine the activity of Cav-1 from PCa TDE, 100 μg of TDE containing the same amount of Cav-1 as the previous experiments using rCav-1 were added into WT LNCaP as a recipient cell and the data demonstrated that TDE derived from Cav-1-positive cells could significantly induce prostate sphere formation (Fig. 4e).