Noticeably, our data unveiled a significant elevation of Cav-1 expression in an AR-positive adenocarcinoma cell model containing both p53 and Rb gene knockout (both mutations are commonly found in CRPC patients associated with NED phenotypes)30,31,59; this cell line acquires lineage plasticity owing Sox2 gene expression through transdifferentiation. Here, SOX2 is linked to adenocarcinoma.