Herein, we identified Alix and CD9 as the common biomarkers for PCa TDEs and demonstrated that the presence of Cav-1 in TDEs from PCa functioned as a potent inducer of CSC in recipient cells by triggering the same signaling pathway as membrane form of Cav-1, implying TDEs can be a potential prognostic marker for CRPC patients. This evidence concerns the gene CD9 and posterior cortical atrophy.