By analysis of the tissue microarray containing 180 pairs of samples, we found 43 of 62 (69.4%) CRC patients with distant metastasis but only 60 of 118 (50.8%) CRC patients without distant metastasis had high RBBP6 expression (Table 2 and Fig. 1f, g). The gene discussed is RBBP6; the disease is colorectal carcinoma.