We then found that the oncogenic transcription factor including MAX, SP1, EGR1, JUND, YY1, ELF1, ATF3, and FOSL1 were all bound at the promoter region of RBBP6, suggesting that the RBBP6 was activated by the multi-oncogenic transcription factor and all of these oncogenic transcription factors might contribute to RBBP6 activation in CRC (Fig. 8b). Here, ATF3 is linked to colorectal carcinoma.