Correspondingly, either exogenous IκBα-M or NF-κB inhibitor BAY11-7082 treatment dramatically abolished the effects of RBBP6-overexpression on CRC cell migration and invasion, whereas the overexpression of p65 restored the effects of RBBP6-sh on CRC cell migration and invasion (Fig. 7c, d; Supplementary Fig. 6). The gene discussed is RELA; the disease is colorectal carcinoma.