SMAD5 and breast cancer: GCBI database analysis using Regulome Explorer (https://www.gcbi.com.cn/) predicted that UTX is regulated by the transcription factor GATA3, GATA1, and several other key transcription factors such as YY1, FOXO1, SMAD5, and SMAD2 (Fig. 1a), this finding suggests that GATA transcription factor expression could be linked to UTX levels in breast cancer.