Other examples include a case of a 13-year-old obese girl with elevated levels of blood glucose and beta-cell antibodies that was treated with insulin injections instead of blood glucose-reducing drugs, and another 13-year-old girl with T1D, but with excess weight resulting in insulin insensitivity, treated with metformin additionally to her very high insulin dosages27. The gene discussed is INS; the disease is type 1 diabetes mellitus.