The total amount of IL-1β in gingival crevicular fluid (GCF), which has been shown to be related to the severity of periodontitis,39 also decreases after non-surgical periodontal therapy (NSPT).40 Moreover, activation of the NLRP3 inflammasome, which mediates the cleavage of pro-IL-1β into its active form, was also observed in the periodontal tissue of periodontitis patients.41,42. The gene discussed is NLRP3; the disease is periodontitis.