Expression of genes involved in mevalonate pathway, such as Hmgcs1, Hmgcr, Mvk, Mvd, and Idi1, appeared to be significantly enriched (P < 0.05, FDR < 0.25) in ASPP2-depleted HCC-LM3 cells (Fig. 1b). This evidence concerns the gene IDI1 and hepatocellular carcinoma.