Historically, neurodegeneration of dopaminergic (DAergic) neurons in substantia nigra pars compacta (SNc) and α-synuclein inclusions in Lewy bodies and Lewy neurites are the histopathological hallmarks of Parkinson’s disease (PD; Spillantini et al., 1997; Antony et al., 2013). This evidence concerns the gene SNCA and Parkinson disease.