The partly shared clinical and histopathological manifestation of idiopathic/sporadic and LRRK2 PD is suggestive of at least some shared physiopathological mechanisms between LRRK2 PD and sporadic PD, thereby supporting a potential for LRRK2 inhibition in the modulation of common pathways in the disease mechanisms. Here, LRRK2 is linked to Parkinson disease.