LRRK2 and Parkinson disease: Previous reports using acute or chronic LRRK2 inhibition have shown preclinical modulatory and protective effects of LRRK2 inhibition in α-synuclein-based PD models, supporting a pathophysiological interaction between LRRK2 kinase function and α-synuclein-induced pathology (Lin et al., 2009; Daher et al., 2015; Andersen et al., 2018a).