EHMT1 inhibitor BIX-01294 [HG(4 d)+LG(4 d)/BIX-01294] had no effect on EHMT1 expression, while both the shEHMT1 lentivirus and BIX-01294 completely restored hyperglycemia-induced SOD2 suppression (Fig. 2H). Here, EHMT1 is linked to Hyperglycemia.