The results showed that the binding ability of Egr1 on the SOD2 promoter was significantly decreased to 51% compared to the control group after 8 d in LG [LG(8 d)], and this effect was completely restored by infection of SOD2 on day 4 after the 4-d HG treatment [HG(4 d)+LG(4 d)/↑SOD2; Fig. 2E]. The gene discussed is EGR1; the disease is infection.