We found that hyperglycemia-induced SOD2 reporter suppression occurred among the −2,000, −1,600, −1,200, −800, −400, −300, and −0 deletion constructs (numbered according to Ensembl gene ID SOD2-201 ENST00000337404.8; transcription start site was marked as 0), while suppression was significantly restored in the −200 and −100 deletion reporter constructs, indicating that hyperglycemia-responsive transcriptional element is located in the range of approximately −300 to −100 on the SOD2 promoter (Fig. 2A). This evidence concerns the gene SOD2 and Hyperglycemia.