The results showed that hyperglycemia treatment had no effect on the methylation of H3K9me3, H3K27me2, and H3K27me3, while methylation of H3K9me2 increased to 215% as a result of HG(4 d)+LG(4 d) treatment compared to LG(8 d) treatment; on the contrary, infection of either SOD2 [HG(4 d)+LG(4 d)/↑SOD2] or Egr1 [HG(4 d)+LG(4 d)/↑Egr1] completely restored this effect. Here, EGR1 is linked to infection.