We first evaluated gene expression, and we found that the maternal diabetes group (STZ/Pre-VEH) decreased mRNA expression of SOD2 and ERβ to 58% and 62%, respectively, compared to the control (CTL/Pre-VEH) group, and that prenatal treatment of either SOD mimetic (STZ/Pre-MnTBAP) or resveratrol (STZ/Pre-RSV) completely restored this effect (Fig. 7A). Here, ESR2 is linked to diabetes mellitus.