Nonetheless, histology remains a seminal discriminator, as many other CNS tumors carry the BRAF V600E mutation, including both primary CNS (i.e., pleomorphic xanthoastrocytoma, ganglioglioma, pilocytic astrocytoma, papillary craniopharyngioma) and metastatic CNS tumors (i.e., melanoma, carcinomas including colorectal cancer). Here, BRAF is linked to melanoma.