This study specifically excluded such cases, including mixed histiocytosis, which needs further investigation to understand whether BRAF V600E mixed pediatric CNS LCH-JXG lesions also share a common hematopoietic precursor, similar to adult BRAF V600E LCH-ECD histiocytosis [4, 34]. Here, BRAF is linked to Langerhans cell histiocytosis.