In the post-BRAF era, we now turn our attention to the molecular classification of histiocytic neoplasms as an area of ongoing, active investigation, which now includes extracutaneous JXG with BRAF V600E and MAPK pathway mutations, in addition to LCH and ECD with BRAF V600E mutations, and even rare reports of RDD with BRAF V600E [25, 44]. This evidence concerns the gene BRAF and histiocytic neoplasm.