Interestingly, promotion effects of HNF-1α and HNF1A-AS1 were reversed when SHP-1 enzymatic activity was inhibited, demonstrating that HNF-1α/HNF1A-AS1/SHP-1 axis is involved in the anti-HCC actions and presents a potential treatment option [26]. The gene discussed is HNF1A; the disease is hepatocellular carcinoma.