J. Shen et al. reported that p62-mediated Keap1/Nrf2 signaling pathway could induce IFNα antiviral response inhibits HCV replication [38], whereas Sun X et al. reported that activation of the p62-Keap1-Nrf2 pathway protects against ferroptosis in hepatocellular carcinoma cells [39]. The gene discussed is SQSTM1; the disease is hepatocellular carcinoma.