FOXR1 and neoplasm: 11q23.3 deletion results in either mixed-lineage leukemia (MLL) or platelet activating factor acetylhydrolase 1b catalytic subunit 2 (PAFAH1B2) fusing to the proximal side of FOXR1. The new fusion transcripts stimulate the overexpression of FOXR1. Functional analyses have shown that FOXR1 overexpression could promote cell proliferation and may be a tumor-driving event [33].