Comparison of the SIRT1 levels between different short-term responses showed that the levels were higher in the Non-responder group (61.1 ± 11.9(%)) than in the Responder group (25.1 ± 17.3(%)) (Fig. 4), and Spearman’s rank correlation coefficient showed a negative correlation between the SIRT1 levels of the tumours and the short-term response (ρ = − 0.710, P < 0.01). This evidence concerns the gene SIRT1 and neoplasm.