The mean concentrations of NfL in the CSF and serum were significantly higher in SCA3 patients than controls (4262.00 ± 1762.00 pg/mL vs 471.70 ± 210.40 pg/mL, p < 0.0001; 41.50 ± 14.78 pg/mL vs 9.10 ± 3.29 pg/mL, p < 0.0001; Fig. 1a-b, Table 1). Here, NEFL is linked to Spinocerebellar ataxia type 3.