NEFL and Spinocerebellar ataxia type 3: Levels of serum NfL were significantly higher in preclinical SCA3 (15.03 ± 7.49 vs 6.88 ± 2.72 pg/ mL, p < 0.0001) and manifest SCA3 (37.56 ± 13.47 vs 9.07 ± 6.02 pg/ mL, p < 0.0001) compared to controls (Table 1 and Fig. 2a).