In order to further investigate whether endogenous IL-8 regulates the expression of integrin β3 in HCC cells, we transfected HCCLM3 and MHCC97H cells with IL-8 siRNA, which led to a significant decrease in the expression of integrin β3 and reduced the invasion and migration of HCCLM3 and MHCC97H cells. Here, CXCL8 is linked to hepatocellular carcinoma.