In this study, we confirmed that knocking down IL-8 resulted in significant decrease in integrin β3, p-PI3K, and p-Akt levels and reduced the invasion of HCCLM3 and MHCC97H cells, suggesting that integrin β3 and PI3K/Akt were involved in IL-8-mediated invasion of HCC cells. Here, CXCL8 is linked to hepatocellular carcinoma.