ARSA and metachromatic leukodystrophy: Three other variants in the ARSA gene are thought to be associated with adult MLD without PNS involvement: c.661 T > G (p.Phe221Val; homozygous) [25], c.878G > A (p.Arg293Gln) and c.1465 T > G (p.Cys489Gly) [24].