AFP and hepatocellular carcinoma: Considering that the REACH-2 study confirmed the result of subgroup analysis in the REACH trial, which is the first positive phase III trial performed in a biomarker-selected patient population with advanced HCC, on May 10, 2019, the FDA approved ramucirumab as a single agent for HCC in patients who have an AFP ≥400 ng/mL and have been previously treated with sorafenib.