Consistent with this, we show here for the first time in DLBCL that high PHB2 expression is associated with high level of Ki-67; moreover PHB1 and PHB2 score expressions were correlated with marker of tumor burden in DLBCL patients (i.e. elevated serum LDH) and PHB2 expression with IPIaa that remains an important prognostic tool for evaluating DLBCL patients. Here, PHB2 is linked to diffuse large B-cell lymphoma.