As for all DLBCL tested, this effect was associated with a reduction of phospho-C-Raf (Additional file 1: Figure S4), phospho-PHB1 (Additional file 1: Figure S6), Akt, MNK1, phospho-eIF4E, Bcl-2 and c-Myc protein expression (Fig. 6c and d), and a significant decrease in AKT1 and AKT2 mRNA levels (Fig. 6e). This evidence concerns the gene RAF1 and diffuse large B-cell lymphoma.