After adjustment of male, age, smoking, drinking, hypertension, diabetes, TG, TC, HDL-C and LDL-C, SOAT1 methylation levels were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150–0.561) (Table 5). The gene discussed is SOAT1; the disease is coronary artery disorder.