We next evaluated a number of other predefined immune gene signatures contained within the IO360 panel for their association with response in the NSCLC cohort and identified several signatures that were statistically significant, including IFNγ signaling, lymphoid cells, T cell, NK cells, cytotoxic cells, exhausted CD8 T cells, macrophages, stroma, inflammatory chemokines, and immunoproteasome (Fig. 3a). This evidence concerns the gene IFNG and non-small cell lung carcinoma.