For example, systematic challenge of prenatal or neonatal mice with lipopolysaccharide (LPS; a TLR4 agonist) or poly(I:C) (a TLR3 agonist) causes autism-like (e.g. impaired social interaction) and schizophrenic-like behaviors, and increases anxiety [31, 74, 75]. This evidence concerns the gene TLR3 and Anxiety.