However, further experiments are required, such as detection of TLR and NF-κB signalings in AhR or CYP1A1 knockdown periodontal cells in the periodontitis environment after 1,25D3 treatment, to fully address the interaction between different pathways and the precise mechanisms of 1,25D3 in periodontitis attenuation. Here, CYP1A1 is linked to periodontitis.