It has been broadly reported to induce host cells like oral epithelial cells to produce a wide range of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8), promoting periodontitis progression [3, 4]. The gene discussed is CXCL8; the disease is periodontitis.