Compared with the HF group, administration of Maoberry extract at three different dosages and of STAT in rats fed a high fat diet showed dramatic downregulation of hepatic TNF-α mRNA expression by 75.5, 5.8, 87.4 and 87.7% for the ML, MM, MH and STAT groups, respectively, as well as significantly decreased hepatic expression of IL-6 by 86.5, 69.3, 94.2 and 94.2%, respectively, (P < 0.05). Here, IL6 is linked to hydrops fetalis.