In Yang T’s biopsy cohort [21], they had 34.6% patients with a PSA level ≥ 20 ng/ml, 33.6% PCa patients with a Gleason score ≥ 8, and a total PC detection rate of 45.6%, similar to the results found in our study (32.5, 37.5, and 48.4%, respectively). Here, KLK3 is linked to posterior cortical atrophy.