Remarkably, we observed strong positive correlations between Treg and JAK-STAT scores, suggesting that tumor tolerance was enhanced in patients with hyperactive JAK-STAT signaling: glioma (rho = 0.85, P < 0.0001), pan-kidney (rho = 0.88, P < 0.0001) and clear cell renal cell (rho = 0.83, P < 0.0001) (Fig. 6a). The gene discussed is SOAT1; the disease is central nervous system cancer.