Given that T cell physiology, such as activation, proliferation and antigen recognition, can profoundly impact the onset and outcome of viral infection, and that the completion of productive infection by retroviruses, such as HIV, significantly depends on T cell activation [41], it would be interesting to explore whether LY6E signaling regulates the host adaptive immunity to viral infection by influencing the TCR-mediated antigen recognition in vivo. This evidence concerns the gene LY6E and viral infectious disease.