LCAT and Fish-eye disease: Our data are in agreement with the fact that previously reported LCAT mutations causing FED are located in the same domains of LCAT gene as those causing FLD, such as, for example, the mutations p.(Pro34Gln) [25] and p.(Pro34Leu) [26], reported in FED and FLD, respectively, although both are located in the same amino acid and in close proximity to the oxyanion hole amino acid 31 [23].