APOB and hyperinsulinemic hypoglycemia, familial, 4: To date, renal disease has been attributed to the cholesterol esterification of lipoproteins containing apolipoprotein B (VLDL and LDL) [7,8], but we report here two siblings with LCAT deficiency, who share the same LCAT mutation and negligible LCAT activity, only one of whom developed renal disease, which suggests that other genetic or environmental factors can influence the development of renal disease.