It is also evident that, in cases of LCAT deficiency, the complete metabolism of lipoproteins would be altered, presenting larger VLDL with a high concentration of free cholesterol and of phospholipids in plasma and glomeruli, which all may be factors in the deterioration of kidneys in patients with a familial LCAT deficiency [28]. This evidence concerns the gene LCAT and hyperinsulinemic hypoglycemia, familial, 4.