Of note, no major variation on global pattern of cytokines production was detected in RA patients when comparing untreated and MTX-treated samples (Figure S7A) and a rather modest increase of IL-17A+ and IFN-γ+/IL-17A+ coproducing cells was observed in MTX-treated PsA patients compared to untreated ones (Figure S7B). This evidence concerns the gene IFNG and rheumatoid arthritis.