In our setting, no striking modifications of the polyfunctionality (IFN-γ, IL-17A, and TNF-α) of CD73+ and CD73neg Teff was noticed in untreated RA and PsA patients compared to HD (Figure 2A) and global levels of each cytokine were unchanged (Figure S4A). The gene discussed is NT5E; the disease is rheumatoid arthritis.