ENTPD1 and rheumatoid arthritis: Dampened or inefficient Treg suppressive functions described by others in RA and PsA patients [32] could partly result from this decreased expression of CD73 on activated Teff, as it may impair CD39+ Treg and CD73+ Teff cooperation for self-inhibition through autocrine Ado production that will act only in a nearby environment due its very short half-life.