To study the role of Fbxo9 in inv(16) AML, we crossed our MxCreFbxo9f/f mouse with the floxed allele of Cbfb-MYH11 (Cbfb+/56M), which allows for the inducible expression of CBFβ-SMMHC following administration of Poly(I:C) [32]. Here, FBXO9 is linked to acute myeloid leukemia.