FBXW7 and chronic myelogenous leukemia, BCR-ABL1 positive: FBXW7, for example, plays an integral role in hematopoietic stem and progenitor cell (HSPC) self-renewal, and its loss has been linked to drug-resistant T-cell acute lymphoblastic leukemia, whereas loss of chronic myeloid leukemia (CML) inhibits the initiation and progression of disease [17,18,19].