PAPSS2 and cancer: Interestingly, a number of the top upregulated proteins identified (SERPINB1, ADK, ARF1, UAP1L1, CAPG, FMNL1, PAPSS2, USP5, and GOLPH3) have been shown to participate in cancer by increasing cell growth and metastasis, or are biomarkers for poor outcomes (Figure 6F) [34,35,36,37,38,39,40,41,42].