In support of these findings, 16 weeks of resistance training increased skeletal muscle GLUT4 protein content in middle-aged (30–54 years) prediabetic, obese men [95] and increased the hypomethylation (promotes gene transcription) of the GLUT4 promoter in middle-aged morbidly obese Maori and Pacific Islanders diagnosed with type 2 diabetes [96]. Here, SLC2A4 is linked to type 2 diabetes mellitus.