Likewise, persistent STAT5 activity induces (i) transformation, (ii) proliferation, and (iii) anti-apoptotic signals that contribute to hematological malignancies, while also suppressing anti-tumor immunity by expanding CD4+/CD25+ regulatory T cells (Tregs) [28,31,32,33,34,35,36]. The gene discussed is STAT5B; the disease is hematologic disorder.