In paired (primary and metastatic) melanomas, the primary tumor of patient 3 exhibited epithelioid morphology (Figure 2, patient 3, A) and was diffusely positive for S100, SOX10, pan-melanocytic cocktail, HMB-45 antigen, and Melan-A (Figure 2, patient 3, A1–A5), whereas the metastatic lesion exhibited rhabdoid morphology (Figure 2, patient 3, B) with patchy expression of S100, SOX10, and pan-melanocytic cocktail, focal expression of HMB-45 antigen, and negative expression of Melan-A (Figure 2, patient 3, B1–B5). This evidence concerns the gene PMEL and melanoma.