The present study has shown that using the same antibiotic treatment approach in immunocompromised patients receiving TNF inhibitor as in immunocompetent patients with EM, while continuing the treatment with a TNF-α inhibitor, resulted in more common treatment failure and more often a complicated course of LB in patients receiving TNF-α inhibitor than in the sex- and age-matched immunocompetent patients with EM. Here, TNF is linked to erythema multiforme.