Differences in the frequency of abnormalities found at physical examination, increased ESR (which is in Europe very rarely associated with erythema migrans), and probably also more frequent comorbidities other than those for which patients were receiving TNF inhibitors could be attributed to patients’ underlying immune-mediated disease, whereas more frequent demonstration of borrelial serum IgM antibodies was possibly the result of false positivity, as reported in several conditions including inflammatory rheumatism [31,32]. The gene discussed is CD40LG; the disease is rheumatic disorder.