STAT3 and infection: Here we confirmed the finding by Puri et al. that the E95D mutation in the V protein inhibits MuV targeting of STAT3 for degradation when assessed 48 h post-infection [34], however, when observation was continued to later time points, it was clear that the E95D substitution does not completely abrogate V protein ability to degrade STAT3 and that STAT3 levels were nearly as low as those seen in cultures infected with the parental wild type virus.