TFF1 and chronic rhinosinusitis with nasal polyps: Conversely, the TFF1 gene was significantly downregulated in all tissue samples from CRSwNP patients taken at the time of FESS surgery compared to the control INT samples, including NP (4.13-fold, p = 0.0001, Figure 1A), MNT-0 (3.13-fold, p = 0.036, Figure 1B) and BE (4.85-fold, p = 0.017, Figure 1C).