They are present in control individuals [45]; the Δ11q protein isoform is seen in cell lines lacking the full-length BRCA1 protein, due to truncating mutations in exon 11 [46]; and BRCA1-IRIS overexpression is found in aggressive breast and ovarian cancers [47,48], introducing it as a drug target [49,50,51]. The gene discussed is BRCA1; the disease is ovarian cancer.