In our Institution, from 2014 through 2016, we evaluated 375 patients with hematological malignancies (Figure 1); mo-MDSCs were identified as CD45+CD33+CD15-CD14+HLA-DR- in peripheral blood according to our internal procedure previously described [19,20], and we found that in comparison with a pool of 45 healthy subjects, mo-MDSCs were increased in all newly-diagnosed patients tested, except those affected by Waldenstrom disease. The gene discussed is CD33; the disease is hematologic disorder.