In this study, our main objective was to investigate whether two functional SNPs of the ADRB2 gene, rs1042713 (16Arg > Gly) and rs1042714 (27Gln > Glu), and their haplotypes were associated with risk of exacerbations in COPD patients treated with inhaled β2-agonists. Here, ADRB2 is linked to chronic obstructive pulmonary disease.