The integrated Mi-2/NuRD CRC includes one chromodomain-helicase-DNA-binding protein, CHD (either CHD3 or 4), one histone deacetylase, HDAC (HDAC1 or 2), two deleted in oral cancer 1 (DOC1, also known as cyclin-dependent kinase 2-associated protein 1), three metastasis-associated, MTA (MTA1, 2, and 3), six nucleosome-remodeling factor subunit RBAP46 or RBAP48, two transcriptional repressor p66 (p66α or β), and MBD (MBD2 or 3) molecules [15]. Here, CHD3 is linked to colorectal carcinoma.