EPO and anemia: The most common causes of MM-related anaemia are: displaced erythroid system by neoplastic plasmacytes, proinflammatory activity of cytokines, disabled apoptosis of the erythroid system, inadequate excretion of erythropoietin (EPO) compared to the degree of anaemia, reduction of erythrocytes’ survival time (<10%), inadequacy of ferric management and direct suppression of erythropoiesis by neoplastic cells [17].