Since the two RAD6 paralogs, RAD6A and RAD6B localized on chromosomes Xq24–25 and 5q23–31, respectively, encode for RAD6 proteins with ~95% amino acid sequence identity, we performed TCGA analysis to compare RAD6A and RAD6B expression levels and copy number alterations in melanoma patients. This evidence concerns the gene UBE2A and melanoma.