CYFIP2 (cytoplasmic FMR1-interacting protein 2) forms part of the VEGFA–VEGFR2 pathway and is associated in humans with susceptibility to Kawasaki disease and coronary artery lesions [29], interacting with PDE2A so that high-risk allele combinations account for 67% of cases in this human population. This evidence concerns the gene PDE2A and Kawasaki disease.