AKT1 and cancer: The sustained activation and expression level of RTKs have been found to be correlated with the abnormalities in the downstream signaling pathways such as mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and Janus kinase/signal transducers, and activators of transcription (JAK/STAT) pathways, which may finally result in cancer development and uncontrolled proliferation of the cells [94,95].